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Dapoxetine
Clinical data
Trade namesPriligy, others (see below)
AHFS/Drugs.comInternational Drug Names
Routes of administrationOral (tablets)
ATC codeG04BX14 ( WHO )
Legal status
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Pharmacokinetic data
Bioavailability15–76% (mean 42%), T max = 1–1.3 hours
Protein binding>99%
MetabolismLiver (CYP2D6, CYP3A4), kidney (FMO1)
MetabolitesDapoxetine- N -oxide, desmethyldapoxetine, didesmethyldapoxetine
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Subjects could request an adjustment in treatment dosage based on resource response.

Use with caution in patients who have conditions which may predispose them to priapism sickle cell anemia, multiple myeloma, leukemia. Patients who are using potent CYP3A4 inhibitors including ketoconazole, ritonavir, atazanavir, clarithromycin, indinavir, itraconazole, nefazodone, nelfinavir, saquinavir and telithromycin see sections 4.

Cardiovascular status Prior to initiating any treatment for erectile dysfunction, physicians should consider the cardiovascular status of their patients since there is a degree of cardiac risk associated with sexual activity see section 4.

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