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Toprol (metoprolol, metoprolol) 100 mg, tablets are debossed with pfizer on one side and vgr25.

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Clinical data
Pronunciation/ m ɛ ˈ t oʊ p r oʊ l ɑː l /, / m ɛ t oʊ ˈ p r oʊ l ɑː l /
Trade namesLopressor, Metolar XR, others
License dataUS   FDA: Metoprolol
Pregnancy categoryAU: C US: C (Risk not ruled out)
Routes of administrationBy mouth, IV
Drug classBeta blocker
ATC codeC07AB02 ( WHO )
Legal status
Legal statusIn general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability50% (single dose) [1] 70% (repeated administration) [2]
Protein binding12%
MetabolismLiver via CYP2D6, CYP3A4
Elimination half-life3–7 hours

Bronchospastic Diseases: Risk of Anaphylactic Reaction: Other reported clinical experience in myocardial infarction has not identified differences in response between the elderly and younger patients.

Regardless, agents such as labetalol, which have alpha and beta activity, or calcium channel blockers should be used in these cases. Inactive Ingredients.

An infant consuming 1 liter of breast milk daily would receive a dose of less than 1 mg of the drug. Hypersensitivity to metoprolol and related derivatives, or to any of the excipients; hypersensitivity to other beta-blockers cross sensitivity between beta-blockers can occur.

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Vertigo, sleep disturbances, hallucinations, headache, dizziness, visual disturbances, confusion, and reduced libido have also been reported, but a drug relationship is not clear. Initial treatment consisted of intravenous followed toprol contraindications oral administration of Metoprolol or placebo, given in a coronary care or comparable unit. A controlled, comparative, clinical trial showed that Metoprolol was indistinguishable from propranolol in the treatment of angina pectoris.

metoprolol trade name

Because animal reproduction studies are not always cialis and tinnitus of human response, this drug should be used during pregnancy only if clearly needed.

Who might need a lower metoprolol dose or extra monitoring? AV Block: Metoprolol produces a decrease in sinus heart rate in most patients; this decrease is greatest among patients with high initial heart rates and least among patients with low initial heart rates.

Do not confuse metoprolol tartrate with metoprolol succinate. MI— 25—50 mg starting 15 min after last IV dose q 6 hr for 48 hr, toprol contraindications mg twice daily. There is very limited experience with the use of hemodialysis to remove metoprolol, however metoprolol is not highly protein bound. On the basis of the pharmacologic actions of metoprolol, employ the following measures.

Metoprolol may hide the symptoms of low blood sugar, such as increased heart rate and tremor. Reproduction toxicity studies in mice, rats and rabbits did not metoprolol contraindications teratogenic potential for metoprolol tartrate.

Metoprolol should not be used during metoprolol contraindications unless considered essential by your doctor. Because coronary artery disease is common and may be unrecognized, it may be prudent not to discontinue metoprolol therapy abruptly even in patients treated only for hypertension.

Monitor heart rate and PR interval. Distribution studies in mice confirm exposure of the fetus when Metoprolol is administered to the pregnant animal. Concomitant use can increase the risk of bradycardia.

Use During Major Surgery Chronically administered beta-blocking therapy should not be routinely withdrawn prior to major surgery; however, the impaired ability of the heart to respond to reflex adrenergic stimuli may augment the risks of general anesthesia and surgical procedures.

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Reproduction toxicity studies in mice, rats and rabbits did not indicate teratogenic potential for metoprolol tartrate. Stroke volume, diastolic blood pressure and pulmonary artery end diastolic pressure remained unchanged. Tablets contain colloidal silicon dioxide, hydroxypropyl methylcellulose, lactose monohydrate, magnesium stearate, microcrystalline cellulose, polyethylene glycol, polysorbate, povidone, sodium starch glycolate, talc and titanium dioxide.

Administration of beta-blockers alone in the setting of pheochromocytoma has been associated with a paradoxical increase in blood pressure metoprolol contraindications and precautions to the attenuation of beta-mediated vasodilatation in skeletal muscle.

Musculoskeletal pain, blurred vision, and tinnitus have also been reported. Sympathetic stimulation is a vital component supporting circulatory function in congestive heart failure, and beta blockade carries the potential hazard of further depressing myocardial contractility and precipitating more severe failure. Calcium channel blockers:

In metoprolol contraindications, possibly significant hypertension may theoretically occur source to 14 days following discontinuation of the concomitant administration with an irreversible MAO inhibitor. Who should not take metoprolol? If a dose should be missed, the patient should take only the next scheduled dose without doubling it.

The only histologic changes that appeared to be drug related were an increased incidence of generally mild focal accumulation of foamy macrophages in pulmonary alveoli and a slight increase in biliary hyperplasia.

Vomiting was a common occurrence. See combination drugs.

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Metoprolol contraindications and precautions
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Metoprolol (Metoprolol Tartrate)

Bronchospastic Diseases: In Patients Without a History of Cardiac Failure Continued depression of the myocardium with beta-blocking agents over a period of time can, in some cases, lead to cardiac failure.

Who might need a lower metoprolol dose or extra monitoring? Do not confuse Toprol-XL metoprolol with Topamax topiramate or with 25 mg metoprolol pill. Information for Patients Patients should be advised to take metoprolol regularly and continuously, as toprol contraindications, with or immediately following meals.

Take apical pulse before administering. Beta-blocker overdose may result in significant resistance to resuscitation with adrenergic agents, including beta-agonists. IV vasoactive medications are inherently dangerous. Administer undiluted.

Appropriate therapy with fluids, positive inotropic agents, balloon counterpulsation, or other treatment modalities should be instituted. Before administering metoprolol contraindications, have second practitioner independently check original order and dose calculations.

Metoprolol versus thiazide diuretics in hypertension. There are immediate and extended-release preparations available orally.

  • Very rarely, photosensitivity and worsening of psoriasis has been reported
  • Post-marketing experience reveals very rare reports of hepatitis, jaundice and non-specific hepatic dysfunction
  • Metoprolol should not be used during pregnancy unless considered essential by your doctor
  • Tiredness has been reported in about 1 of patients
  • People with an untreated tumour of the adrenal gland phaeochromocytoma

Metoprolol contraindications

If cardiac failure continues, despite adequate digitalization and diuretic therapy, metoprolol should be withdrawn. Major Surgery: Hypersensitivity to metoprolol and related derivatives, or to any of the excipients; hypersensitivity to other beta-blockers cross sensitivity between beta-blockers can occur.

Depression has been reported in about 5 of patients or bystolic to metoprolol. Avoid drinking alcohol while you are using the extended-release capsules.

Drug manufacturers, however, are unable to advertise beta blockers for other purposes that have not been approved by the FDA. Consider intravenous vasopressor infusion, such as dopamine or norepinephrine.

Extended-release tablets succinate; Toprol XL: Beta-blockers may increase sensitivity to allergens and result in more serious allergic reactions; they may also reduce metoprolol contraindications response to adrenaline used to treat anaphylactic shock,


Regardless, agents such as labetalol, which have alpha and beta activity, or calcium channel blockers should be used in these cases.

Catecholamine-depleting drugs e. Since beta1 selectivity is not absolute, a beta2-stimulating agent should be administered concomitantly, and the lowest possible dose of metoprolol tartrate should be used.

Increase in plasma concentrations of metoprolol would decrease the cardioselectivity of metoprolol.

If a dose should be missed, the patient should take only the next scheduled dose without doubling it. There are no adequate and well-controlled studies in pregnant women. Pediatric Use Safety and effectiveness in pediatric patients have not been established.

Tell your doctor if your breathing problems get worse after starting metoprolol. These limited animal studies do not indicate direct or indirect harmful effects with respect to teratogenicity see Carcinogenesis, Mutagenesis, Impairment of Fertility.

See combination drugs.

Because of relative beta1 metoprolol contraindications, however, metoprolol may be used with caution in patients with bronchospastic disease who do not respond to, or cannot tolerate, other antihypertensive treatment.

Increase in plasma concentrations of metoprolol would decrease the cardioselectivity of metoprolol.

Cold extremities; arterial insufficiency, metoprolol contraindications of the Raynaud yasmin song palpitations; congestive heart failure; peripheral edema; and hypotension have been reported in about 1 of patients.

Other clinical manifestations of overdose should be managed symptomatically based on modern methods of intensive care. While taking beta-blockers, patients with a history of severe anaphylactic reaction to a variety of allergens may be more reactive to repeated challenge, either accidental, diagnostic, or therapeutic. Metoprolol metoprolol contraindications, USP is a white, practically odorless, crystalline powder with a molecular weight of and

Extended-release tablets should be swallowed whole; do not break, crush, or chew. In shock resulting from inadequate cardiac contractility, administration of dobutamine, isoproterenol, or glucagon may be considered.

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