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Methotrexate Injection: MedlinePlus Drug Information

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Methotrexate (methotrexate, methotrexate) 2 mg, should be taken approximately 30-60 minutes before intended sexual activity and on an empty stomach.

Methotrexate film-coated. The dose may be increased to a maximum recommended dose of 100 mg or decreased to 25 mg.

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Methotrexate
Clinical data
Pronunciation/ ˌ m ɛ θ ə ˈ t r ɛ k ˌ s eɪ t, ˌ m iː -, - θ oʊ -/  (   listen ) [2] [3] [4]
Trade namesTrexall, Rheumatrex, others [1]
AHFS/Drugs.comMonograph
MedlinePlusa682019
License dataEU  EMA:  by INN, US   FDA: Methotrexate
Pregnancy categoryAU: D US: X (Contraindicated)
Routes of administrationBy mouth, IV, IM, SC, intrathecal
ATC codeL01BA01 ( WHO ) L04AX03 ( WHO )
Legal status
Legal statusAU: S4 (Prescription only) CA : ℞-only UK: POM (Prescription only) US: ℞-only In general: ℞ (Prescription only)
Pharmacokinetic data
Bioavailability60% at lower doses, less at higher doses. [5]
Protein binding35–50% (parent drug), [5] 91–93% (7-hydroxymethotrexate) [6]
MetabolismHepatic and intracellular [5]
Elimination half-life3–10 hours (lower doses), 8–15 hours (higher doses) [5]
ExcretionUrine (80–100%), faeces (small amounts) [5] [6]

Unless your doctor tells you otherwise, continue your normal diet. Self-management If you will be self-injecting methotrexate, your healthcare provider will show you or your caregiver how to do it. If you have psoriasis, your sores may get worse if you expose your skin to sunlight while you are receiving methotrexate. Follow all directions on your prescription label and read all medication guides or instruction sheets.

Keep this medication away from light. Tell your doctor if you have or have ever had stomach ulcers azulfidine pfizer ulcerative colitis a condition which causes swelling and sores in the lining of the colon [large intestine] and rectum. Some men and women who use this medicine have become infertile unable to have children.

Child dosage ages 0—1 year This drug has not been proven to be safe and effective for children younger than 2 years, methotrexate and thyroid function. Blood and urine tests may be needed to check for unwanted effects.

How do I take it?

See also: Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

Tell your doctor if you are taking any of the following medications: Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

This can help keep levels of this drug from building up too much in your body. What to do if you miss a dose:

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When methotrexate is used with certain drugs, it may not work as well to treat your condition. How should this medicine be used?

This drug can make these problems worse. These problems can be fatal cause death. Keep it in your carry-on bag.

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Call your doctor immediately if you experience any of the following symptoms: This medicine may cause a serious reaction called tumor lysis syndrome.

You must use an effective form of birth control while taking methotrexate and for at least 3 months after the methotrexate is stopped. This can cause liver damage or worsen liver problems that you already have. Methotrexate may cause liver damage, especially when it is taken for a long period of time.

Some examples of live vaccines include measles, mumps, influenza nasal flu vaccinepoliovirus oral formrotavirus, and rubella. Wash hands before and after removing gloves, methotrexate and mouth sores.

You must use the correct dose for your condition. The dose is generally given once per day for several days and then repeated after a rest period.

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Important Information

Methotrexate can lower the number of white blood cells in your blood, which increases the chance of getting an infection. Methotrexate may treat rheumatoid arthritis by decreasing the activity of the immune system. Your doctor will monitor you carefully and treat these complications if they occur.

Depending on your level of liver disease, your doctor may decide that you should not take methotrexate. Live vaccines.

Be careful when using a regular toothbrush, dental source website, or toothpick.

Avoid driving or operating machinery until you know how this medicine will affect you with methotrexate and vitamins. Important Information Do not use methotrexate to treat psoriasis or rheumatoid arthritis if you have low blood cell counts, a weak immune system, alcoholism or chronic liver diseaseor if you are pregnant or breast-feeding.

When you are taking methotrexate, it is very important that your doctors know if you are taking any other medicine. Check with your doctor right away if you have cough, fever, or shortness of breath.

Methotrexate 50 mg side effects
Always discuss possible side effects with a healthcare provider who knows your medical history If you are male If you experience any of the following symptoms If you need to be sedated for dental work
Why is this medication prescribed?Avoid driving or operating machinery until you know how this medicine will affect you For some conditions Your rheumatologist will prescribe the folic acid
Methotrexate is used to treat certain types of cancer of the breastskin If you are a man This medicine may affect fertility ability to have children in both men and women To help avoid interactions
Tell your doctor if you have or have ever had a low number of any type of blood cells or any other problem with your blood cells Talk with your doctor before using this medicine if you plan to have children Taking methotrexate with certain medications raises your risk of side effects from those drugs These conditions and medications may increase the risk that you will develop serious side effects of methotrexate
What happens if I miss a dose?Side Effects Along with its needed effects See also For seniors

Methotrexate

What happens if I overdose? Dosing The dose of this medicine will be different for different patients. Your doctor may tell you that you should not receive methotrexate unless you have life-threatening cancer. Unless your doctor tells you otherwise, continue your normal diet.

This medicine may affect fertility ability to have children in both men and women. People with RA or psoriasis should not use this drug during pregnancy.

Your doctor may start you on a lower dosage or a different dosing schedule with link web page. A dose of 10 to 30 milligrams mg once per day may be given for several days and then repeated after a rest period and on methotrexate and have a cold.

Check with your doctor right away if you have pain or tenderness in the upper stomach, pale stools, dark urine, loss of appetite, nausea, vomiting, or yellow eyes or skin. This includes prescription or nonprescription over-the-counter [OTC] medicines and herbal or vitamin supplements. Your doctor will monitor you carefully and treat these complications if they occur. Methotrexate can be taken with other medications or tp24.it.

Common side effects may include For psoriasis Adults—At first Methotrexate may cause very serious
These include low counts of white blood cells Some people have died after taking methotrexate every day by accident These could be symptoms of a serious lung or breathing problems Never try to catch up by taking two doses at once
More common blood in the urine or stools bloody vomit Be sure to avoid doing this when the weather is very hot or very cold Your doctor may need to change the doses of your medications or monitor you carefully for side effects Methotrexate may stay in your body for a longer time if you have these medical problems
Methotrexate may cause very serious Methotrexate is usually given after other treatments have failed The effects of methotrexate on joint swelling and tenderness can be seen from 4 to 8 weeks Methotrexate can also cause hair thinning or hair loss
Kisqali Methotrexate interferes with the growth of certain cells of the body Wash hands before and after removing gloves See also For people with pleural effusion or ascites

Methotrexate passes through breast milk and can cause side effects in a child who is breastfed. Post-transplant drugs such as azathioprine.

Adults—At first, 7. Do not use this medicine if it has changed colors or has lumps or particles in it. Women should use birth control during and for at least 6 months click the last dose. Do not touch your eyes or the inside of your nose unless you have just washed your hands and have not touched anything else in the meantime.

Methotrexate is in a class of medications called antimetabolites. Your doctor may order liver biopsies removal of a small piece of liver tissue to be examined in a laboratory before and during your treatment with methotrexate.

Wash soiled clothing and linens separately from other laundry. As a result, more of a drug may stay in your body for a longer time.

Methotrexate may cause harm or death to the fetus. Get your prescription refilled before you run out of medicine completely.

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Methotrexate, 6 reviews:

Comment №1 about product

What happens if I overdose? This may increase the levels of methotrexate in your body and cause more side effects. Precautions It is very important that your doctor check your progress at regular visits to make sure this medicine is working properly and to check for unwanted effects.


5 / 5 stars
Comment №2 about product

Adults—At first, 10 to 25 milligrams mg once per week or 2. Infection bacteria, fungus, virus —Use with caution or narkoza skutki uboczne lexapro.


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Comment №3 about product

Tell your doctor right away if a pregnancy occurs while either the mother or the father is taking methotrexate.


5 / 5 stars
Comment №4 about product

Child dosage ages 0—17 years This drug is not approved to treat RA in children. You should not breast-feed while using this medicine. What to do if you miss a dose:


5 / 5 stars
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Alcohol may increase the risk for liver problems.


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Symptoms can include:


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